A versatile reporter system for CRISPR-mediated chromosomal rearrangements

Although chromosomal deletions and inversions are important in cancer, conventional methods for detecting DNA rearrangements require laborious indirect assays. Here we develop fluorescent reporters to rapidly quantify CRISPR/Cas9-mediated deletions and inversions. We find that inversion depends on t...

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Podrobná bibliografie
Vydáno v:Genome Biol
Hlavní autoři: Li, Yingxiang, Park, Angela I., Mou, Haiwei, Colpan, Cansu, Bizhanova, Aizhan, Akama-Garren, Elliot, Joshi, Nik, Hendrickson, Eric A., Feldser, David, Yin, Hao, Anderson, Daniel G., Jacks, Tyler, Weng, Zhiping, Xue, Wen
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Method
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465146/
https://ncbi.nlm.nih.gov/pubmed/26018130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0680-7
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