A versatile reporter system for CRISPR-mediated chromosomal rearrangements

Although chromosomal deletions and inversions are important in cancer, conventional methods for detecting DNA rearrangements require laborious indirect assays. Here we develop fluorescent reporters to rapidly quantify CRISPR/Cas9-mediated deletions and inversions. We find that inversion depends on t...

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Detalles Bibliográficos
Publicado en:Genome Biol
Main Authors: Li, Yingxiang, Park, Angela I., Mou, Haiwei, Colpan, Cansu, Bizhanova, Aizhan, Akama-Garren, Elliot, Joshi, Nik, Hendrickson, Eric A., Feldser, David, Yin, Hao, Anderson, Daniel G., Jacks, Tyler, Weng, Zhiping, Xue, Wen
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2015
Assuntos:
Method
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465146/
https://ncbi.nlm.nih.gov/pubmed/26018130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0680-7
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