CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer

Small cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer that remains among the most lethal of solid tumor malignancies. Recent genomic sequencing studies have identified many recurrently mutated genes in human SCLC tumors. However, the functional roles of most of these genes rema...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ng, Sheng Rong, Rideout, William M., Akama-Garren, Elliot H., Bhutkar, Arjun, Mercer, Kim L., Schenkel, Jason M., Bronson, Roderick T., Jacks, Tyler
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955235/
https://ncbi.nlm.nih.gov/pubmed/31871154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821893117
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