Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis

Despite the fact that the majority of lung cancer deaths are due to metastasis, the molecular mechanisms driving metastatic progression are poorly understood. Here, we present evidence that loss of Foxa2 and Cdx2 synergizes with loss of Nkx2-1 to fully activate the metastatic program. These three li...

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Detaylı Bibliyografya
Yayımlandı:Genes Dev
Asıl Yazarlar: Li, Carman Man-Chung, Gocheva, Vasilena, Oudin, Madeleine J., Bhutkar, Arjun, Wang, Shi Yun, Date, Saya R., Ng, Sheng Rong, Whittaker, Charles A., Bronson, Roderick T., Snyder, Eric L., Gertler, Frank B., Jacks, Tyler
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2015
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573857/
https://ncbi.nlm.nih.gov/pubmed/26341558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.267393.115
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