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Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis
Despite the fact that the majority of lung cancer deaths are due to metastasis, the molecular mechanisms driving metastatic progression are poorly understood. Here, we present evidence that loss of Foxa2 and Cdx2 synergizes with loss of Nkx2-1 to fully activate the metastatic program. These three li...
Salvato in:
Pubblicato in: | Genes Dev |
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Autori principali: | , , , , , , , , , , , |
Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
Cold Spring Harbor Laboratory Press
2015
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4573857/ https://ncbi.nlm.nih.gov/pubmed/26341558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.267393.115 |
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