Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis

Despite the fact that the majority of lung cancer deaths are due to metastasis, the molecular mechanisms driving metastatic progression are poorly understood. Here, we present evidence that loss of Foxa2 and Cdx2 synergizes with loss of Nkx2-1 to fully activate the metastatic program. These three li...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Li, Carman Man-Chung, Gocheva, Vasilena, Oudin, Madeleine J., Bhutkar, Arjun, Wang, Shi Yun, Date, Saya R., Ng, Sheng Rong, Whittaker, Charles A., Bronson, Roderick T., Snyder, Eric L., Gertler, Frank B., Jacks, Tyler
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2015
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573857/
https://ncbi.nlm.nih.gov/pubmed/26341558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.267393.115
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