FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer

Changes in cancer cell identity can alter malignant potential and therapeutic response. Loss of the pulmonary lineage specifier NKX2-1 augments the growth of KRAS-driven lung adenocarcinoma and causes pulmonary to gastric transdifferentiation. Here, we show that the transcription factors FoxA1 and F...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Camolotto, Soledad A, Pattabiraman, Shrivatsav, Mosbruger, Timothy L, Jones, Alex, Belova, Veronika K, Orstad, Grace, Streiff, Mitchell, Salmond, Lydia, Stubben, Chris, Kaestner, Klaus H, Snyder, Eric L
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303105/
https://ncbi.nlm.nih.gov/pubmed/30475207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38579
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