An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma

Cancer cells undergo lineage switching during natural progression and in response to therapy. NKX2-1 loss in human and murine lung adenocarcinoma leads to invasive mucinous adenocarcinoma (IMA), a lung cancer subtype that exhibits gastric differentiation and harbors a distinct spectrum of driver onc...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Zewdu, Rediet, Mehrabad, Elnaz Mirzaei, Ingram, Kelley, Fang, Pengshu, Gillis, Katherine L, Camolotto, Soledad A, Orstad, Grace, Jones, Alex, Mendoza, Michelle C, Spike, Benjamin T, Snyder, Eric L
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102067/
https://ncbi.nlm.nih.gov/pubmed/33821796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66788
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