In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system

Chromosomal rearrangements play a central role in the pathogenesis of human cancers and often result in the expression of therapeutically actionable gene fusions(1). A recently discovered example is a fusion between the Echinoderm Microtubule-associated Protein-like 4 (EML4) and the Anaplastic Lymph...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nature
Main Authors: Maddalo, Danilo, Manchado, Eusebio, Concepcion, Carla P., Bonetti, Ciro, Vidigal, Joana A., Han, Yoon-Chi, Ogrodowski, Paul, Crippa, Alessandra, Rekhtman, Natasha, de Stanchina, Elisa, Lowe, Scott W., Ventura, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270925/
https://ncbi.nlm.nih.gov/pubmed/25337876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13902
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados