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In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
Chromosomal rearrangements play a central role in the pathogenesis of human cancers and often result in the expression of therapeutically actionable gene fusions(1). A recently discovered example is a fusion between the Echinoderm Microtubule-associated Protein-like 4 (EML4) and the Anaplastic Lymph...
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| 出版年: | Nature |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4270925/ https://ncbi.nlm.nih.gov/pubmed/25337876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13902 |
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