Unexpected genomic rearrangements at targeted loci associated with CRISPR/Cas9-mediated knock-in

The CRISPR/Cas9 gene editing tool enables accessible and efficient modifications which (re)ignited molecular research in certain species. However, targeted integration of large DNA fragments using CRISPR/Cas9 can still be challenging in numerous models. To systematically compare CRISPR/Cas9’s effici...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rezza, Amélie, Jacquet, Christelle, Le Pillouer, Amélie, Lafarguette, Florian, Ruptier, Charlotte, Billandon, Marion, Isnard Petit, Patricia, Trouttet, Séverine, Thiam, Kader, Fraichard, Alexandre, Chérifi, Yacine
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401152/
https://ncbi.nlm.nih.gov/pubmed/30837594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40181-w
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