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Precision cancer mouse models through genome editing with CRISPR-Cas9
The cancer genome is highly complex, with hundreds of point mutations, translocations, and chromosome gains and losses per tumor. To understand the effects of these alterations, precise models are needed. Traditional approaches to the construction of mouse models are time-consuming and laborious, re...
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| Publicado no: | Genome Med |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4460969/ https://ncbi.nlm.nih.gov/pubmed/26060510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0178-7 |
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