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Activating PTEN Tumor Suppressor Expression with the CRISPR/dCas9 System
PTEN expression is lost in many cancers, and even small changes in PTEN activity affect susceptibility and prognosis in a range of highly aggressive malignancies, such as melanoma and triple-negative breast cancer (TNBC). Loss of PTEN expression occurs via multiple mechanisms, including mutation, tr...
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| 出版年: | Mol Ther Nucleic Acids |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Gene & Cell Therapy
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6348769/ https://ncbi.nlm.nih.gov/pubmed/30654190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.12.003 |
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