Activating PTEN Tumor Suppressor Expression with the CRISPR/dCas9 System

PTEN expression is lost in many cancers, and even small changes in PTEN activity affect susceptibility and prognosis in a range of highly aggressive malignancies, such as melanoma and triple-negative breast cancer (TNBC). Loss of PTEN expression occurs via multiple mechanisms, including mutation, tr...

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Publicat a:Mol Ther Nucleic Acids
Autors principals: Moses, Colette, Nugent, Fiona, Waryah, Charlene Babra, Garcia-Bloj, Benjamin, Harvey, Alan R., Blancafort, Pilar
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348769/
https://ncbi.nlm.nih.gov/pubmed/30654190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.12.003
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