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Epigenetic Targeting of Granulin in Hepatoma Cells by Synthetic CRISPR dCas9 Epi-suppressors
The CRISPR-associated Cas9 system can modulate disease-causing alleles both in vivo and ex vivo, raising the possibility of therapeutic genome editing. In addition to gene targeting, epigenetic modulation by the catalytically inactive dCas9 may also be a potential form of cancer therapy. Granulin (G...
Tallennettuna:
| Julkaisussa: | Mol Ther Nucleic Acids |
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| Päätekijät: | , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society of Gene & Cell Therapy
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5849805/ https://ncbi.nlm.nih.gov/pubmed/29858058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.01.002 |
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