CRISPR/dCas-mediated counter-silencing: reprogramming dCas proteins into antagonists of xenogeneic silencers

ABSTRACT Lsr2-like nucleoid-associated proteins function as xenogeneic silencers (XSs) inhibiting expression of horizontally acquired, adenine-thymine-rich DNA in actinobacteria. Interference by transcription factors can lead to counter-silencing of XS target promoters, but relief of this repression...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Johanna Wiechert, Biel Badia Roigé, Doris Dohmen-Olma, Hindra, Xiafei Zhang, Roberto G. Stella, Marie A. Elliot, Julia Frunzke
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology 2025-07-01
Serija:	mBio
Teme:	xenogeneic silencing Lsr2 Actinobacteria CRISPR Corynebacterium phage-host interaction
Online dostop:	https://journals.asm.org/doi/10.1128/mbio.00382-25
Oznake:	Označite Brez oznak, prvi označite!