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Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing
After damage to the adult mammalian central nervous system (CNS), surviving neurons have limited capacity to regenerate and restore functional connectivity. Conditional genetic deletion of PTEN results in robust CNS axon regrowth, while PTEN repression with short hairpin RNA (shRNA) improves regener...
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| Vydáno v: | Sci Rep |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7347541/ https://ncbi.nlm.nih.gov/pubmed/32647121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68257-y |
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