Código QR (código de barras bidimensional)

CRISPR/dCas9-TET1–mediated epigenetic editing reactivates miR-200c in breast cancer cells

Abstract Cancer progression is often accompanied by epigenetic silencing of tumor-suppressor microRNAs such asmiR-200c, a key regulator of epithelial-to-mesenchymal transition (EMT) and metastasis. Given the reversible nature of DNA methylation, we employed a CRISPR/dCas9-TET1 system to target the m...

Fuld beskrivelse

Na minha lista:
Principais autores: Mahyar Zahraei, Yasamin Azimi, Morteza Karimipour, Fatemeh Rahimi-Jamnani, Vahideh Valizadeh, Masoumeh Azizi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-08-01
Serier:Scientific Reports
Fag:
CRISPR/dCas9-TET1
Promoter demethylation
Epigenome editing
Breast cancer
Epithelial mesenchymal transition (EMT)
MicroRNA-200c
Online adgang:https://doi.org/10.1038/s41598-025-16911-8
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker