CRISPR/dCas9-TET1–mediated epigenetic editing reactivates miR-200c in breast cancer cells

Abstract Cancer progression is often accompanied by epigenetic silencing of tumor-suppressor microRNAs such asmiR-200c, a key regulator of epithelial-to-mesenchymal transition (EMT) and metastasis. Given the reversible nature of DNA methylation, we employed a CRISPR/dCas9-TET1 system to target the m...

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主要な著者:	Mahyar Zahraei, Yasamin Azimi, Morteza Karimipour, Fatemeh Rahimi-Jamnani, Vahideh Valizadeh, Masoumeh Azizi
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2025-08-01
シリーズ:	Scientific Reports
主題:	CRISPR/dCas9-TET1 Promoter demethylation Epigenome editing Breast cancer Epithelial mesenchymal transition (EMT) MicroRNA-200c
オンライン･アクセス:	https://doi.org/10.1038/s41598-025-16911-8
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