CD4 mimetics sensitize HIV-1-infected cells to ADCC

HIV-1-infected cells presenting envelope glycoproteins (Env) in the CD4-bound conformation on their surface are preferentially targeted by antibody-dependent cell-mediated cytotoxicity (ADCC). HIV-1 has evolved a sophisticated mechanism to avoid exposure of ADCC-mediating Env epitopes by down-regula...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Richard, Jonathan, Veillette, Maxime, Brassard, Nathalie, Iyer, Shilpa S., Roger, Michel, Martin, Loïc, Pazgier, Marzena, Schön, Arne, Freire, Ernesto, Routy, Jean-Pierre, Smith, Amos B., Park, Jongwoo, Jones, David M., Courter, Joel R., Melillo, Bruno N., Kaufmann, Daniel E., Hahn, Beatrice H., Permar, Sallie R., Haynes, Barton F., Madani, Navid, Sodroski, Joseph G., Finzi, Andrés
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443331/
https://ncbi.nlm.nih.gov/pubmed/25941367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506755112
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi