CD4 mimetics sensitize HIV-1-infected cells to ADCC

HIV-1-infected cells presenting envelope glycoproteins (Env) in the CD4-bound conformation on their surface are preferentially targeted by antibody-dependent cell-mediated cytotoxicity (ADCC). HIV-1 has evolved a sophisticated mechanism to avoid exposure of ADCC-mediating Env epitopes by down-regula...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Richard, Jonathan, Veillette, Maxime, Brassard, Nathalie, Iyer, Shilpa S., Roger, Michel, Martin, Loïc, Pazgier, Marzena, Schön, Arne, Freire, Ernesto, Routy, Jean-Pierre, Smith, Amos B., Park, Jongwoo, Jones, David M., Courter, Joel R., Melillo, Bruno N., Kaufmann, Daniel E., Hahn, Beatrice H., Permar, Sallie R., Haynes, Barton F., Madani, Navid, Sodroski, Joseph G., Finzi, Andrés
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2015
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443331/
https://ncbi.nlm.nih.gov/pubmed/25941367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506755112
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