CD4 mimetics sensitize HIV-1-infected cells to ADCC

HIV-1-infected cells presenting envelope glycoproteins (Env) in the CD4-bound conformation on their surface are preferentially targeted by antibody-dependent cell-mediated cytotoxicity (ADCC). HIV-1 has evolved a sophisticated mechanism to avoid exposure of ADCC-mediating Env epitopes by down-regula...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Richard, Jonathan, Veillette, Maxime, Brassard, Nathalie, Iyer, Shilpa S., Roger, Michel, Martin, Loïc, Pazgier, Marzena, Schön, Arne, Freire, Ernesto, Routy, Jean-Pierre, Smith, Amos B., Park, Jongwoo, Jones, David M., Courter, Joel R., Melillo, Bruno N., Kaufmann, Daniel E., Hahn, Beatrice H., Permar, Sallie R., Haynes, Barton F., Madani, Navid, Sodroski, Joseph G., Finzi, Andrés
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443331/
https://ncbi.nlm.nih.gov/pubmed/25941367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506755112
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki