Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4 + T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity

Human immunodeficiency virus type 1 (HIV-1) infection causes a progressive depletion of CD4 + T cells. Despite its importance for HIV-1 pathogenesis, the precise mechanisms underlying CD4 + T-cell depletion remain incompletely understood. Here we make the surprising observation that antibody-depende...

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Detalles Bibliográficos
Publicado en:EBioMedicine
Main Authors: Richard, Jonathan, Veillette, Maxime, Ding, Shilei, Zoubchenok, Daria, Alsahafi, Nirmin, Coutu, Mathieu, Brassard, Nathalie, Park, Jongwoo, Courter, Joel R., Melillo, Bruno, Smith, Amos B., Shaw, George M., Hahn, Beatrice H., Sodroski, Joseph, Kaufmann, Daniel E., Finzi, Andrés
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2015
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739418/
https://ncbi.nlm.nih.gov/pubmed/26870823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.12.004
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