CD4 mimetics sensitize HIV-1-infected cells to ADCC

HIV-1-infected cells presenting envelope glycoproteins (Env) in the CD4-bound conformation on their surface are preferentially targeted by antibody-dependent cell-mediated cytotoxicity (ADCC). HIV-1 has evolved a sophisticated mechanism to avoid exposure of ADCC-mediating Env epitopes by down-regula...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Richard, Jonathan, Veillette, Maxime, Brassard, Nathalie, Iyer, Shilpa S., Roger, Michel, Martin, Loïc, Pazgier, Marzena, Schön, Arne, Freire, Ernesto, Routy, Jean-Pierre, Smith, Amos B., Park, Jongwoo, Jones, David M., Courter, Joel R., Melillo, Bruno N., Kaufmann, Daniel E., Hahn, Beatrice H., Permar, Sallie R., Haynes, Barton F., Madani, Navid, Sodroski, Joseph G., Finzi, Andrés
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443331/
https://ncbi.nlm.nih.gov/pubmed/25941367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506755112
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