Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1

Improving our understanding of the role of chromatin regulators in the initiation, development, and suppression of cancer and other devastating diseases is critical, as they are integral players in regulating DNA integrity and gene expression. Developing small molecule inhibitors for this target cla...

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Udgivet i:ACS Chem Biol
Main Authors: Perfetti, Michael T., Baughma, Brandi M., Dickson, Bradley M., Mu, Yunxiang, Cui, Gaofeng, Mader, Pavel, Dong, Aiping, Norris, Jacqueline L., Rothbart, Scott B., Strahl, Brian D., Brown, Peter J., Janzen, William P., Arrowsmith, Cheryl H., Mer, Georges, McBride, Kevin M., James, Lindsey I., Frye, Stephen V.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402254/
https://ncbi.nlm.nih.gov/pubmed/25590533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500956g
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