Discovery of a Dual PRMT5–PRMT7 Inhibitor

[Image: see text] The protein arginine methyltransferases PRMT7 and PRMT5, respectively, monomethylate and symmetrically dimethylate arginine side-chains of proteins involved in diverse cellular mechanisms, including chromatin-mediated control of gene transcription, splicing, and the RAS to ERK tran...

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Smil, David, Eram, Mohammad S., Li, Fengling, Kennedy, Steven, Szewczyk, Magdalena M., Brown, Peter J., Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Vedadi, Masoud, Schapira, Matthieu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2015
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394339/
https://ncbi.nlm.nih.gov/pubmed/25893041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500467h
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