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The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase
Schnyder corneal dystrophy (SCD) is an autosomal dominant disorder in humans characterized by abnormal accumulation of cholesterol in the cornea. SCD-associated mutations have been identified in the gene encoding UBIAD1, a prenyltransferase that synthesizes vitamin K(2). Here, we show that sterols s...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4374513/ https://ncbi.nlm.nih.gov/pubmed/25742604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05560 |
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