Enhanced ER-associated degradation of HMG CoA reductase causes embryonic lethality associated with Ubiad1 deficiency

UbiA prenyltransferase domain-containing protein-1 (UBIAD1) synthesizes the vitamin K subtype menaquinone-4 (MK-4). Previous studies in cultured cells (Schumacher et al., 2015) revealed that UBIAD1 also inhibits endoplasmic reticulum (ER)-associated degradation (ERAD) of ubiquitinated HMG CoA reduct...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Jo, Youngah, Kim, Steven S, Garland, Kristina, Fuentes, Iris, DiCarlo, Lisa M, Ellis, Jessie L, Fu, Xueyan, Booth, Sarah L, Evers, Bret M, DeBose-Boyd, Russell A
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069719/
https://ncbi.nlm.nih.gov/pubmed/32118581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54841
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