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Underlying Mechanisms for Sterol-Induced Ubiquitination and ER-Associated Degradation of HMG CoA Reductase
Accelerated ubiquitination and subsequent endoplasmic reticulum (ER)-associated degradation (ERAD) constitute one of several mechanisms for feedback control of HMG CoA reductase, the rate-limiting enzyme in synthesis of cholesterol and nonsterol isoprenoids. This ERAD is initiated by the accumulatio...
Gardado en:
| Publicado en: | Semin Cell Dev Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6341991/ https://ncbi.nlm.nih.gov/pubmed/29107682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2017.10.019 |
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