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UbiA prenyltransferase domain–containing protein-1 modulates HMG-CoA reductase degradation to coordinate synthesis of sterol and nonsterol isoprenoids

UBIAD1 (UbiA prenyltransferase domain–containing protein-1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K(2). We previously reported that sterols stimulate binding of UBIAD1 to endoplasmic reticulum (ER)–localized 3-hydroxy-3-methylglutaryl (HMG) CoA reductase. UBIAD1 binding...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Schumacher, Marc M., Jun, Dong-Jae, Johnson, Brittany M., DeBose-Boyd, Russell A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766919/
https://ncbi.nlm.nih.gov/pubmed/29167270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000423
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