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UbiA prenyltransferase domain–containing protein-1 modulates HMG-CoA reductase degradation to coordinate synthesis of sterol and nonsterol isoprenoids
UBIAD1 (UbiA prenyltransferase domain–containing protein-1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K(2). We previously reported that sterols stimulate binding of UBIAD1 to endoplasmic reticulum (ER)–localized 3-hydroxy-3-methylglutaryl (HMG) CoA reductase. UBIAD1 binding...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5766919/ https://ncbi.nlm.nih.gov/pubmed/29167270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000423 |
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