UbiA prenyltransferase domain–containing protein-1 modulates HMG-CoA reductase degradation to coordinate synthesis of sterol and nonsterol isoprenoids

UBIAD1 (UbiA prenyltransferase domain–containing protein-1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K(2). We previously reported that sterols stimulate binding of UBIAD1 to endoplasmic reticulum (ER)–localized 3-hydroxy-3-methylglutaryl (HMG) CoA reductase. UBIAD1 binding...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Schumacher, Marc M., Jun, Dong-Jae, Johnson, Brittany M., DeBose-Boyd, Russell A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2018
Gaiak:
Lipids
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766919/
https://ncbi.nlm.nih.gov/pubmed/29167270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000423
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