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The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase

Schnyder corneal dystrophy (SCD) is an autosomal dominant disorder in humans characterized by abnormal accumulation of cholesterol in the cornea. SCD-associated mutations have been identified in the gene encoding UBIAD1, a prenyltransferase that synthesizes vitamin K(2). Here, we show that sterols s...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Schumacher, Marc M, Elsabrouty, Rania, Seemann, Joachim, Jo, Youngah, DeBose-Boyd, Russell A
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374513/
https://ncbi.nlm.nih.gov/pubmed/25742604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05560
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