Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice

Autosomal-dominant Schnyder corneal dystrophy (SCD) is characterized by corneal opacification owing to overaccumulation of cholesterol. SCD is caused by mutations in UBIAD1, which utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K(2). Using cultured cells, we previously showed that...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Jo, Youngah, Hamilton, Jason S, Hwang, Seonghwan, Garland, Kristina, Smith, Gennipher A, Su, Shan, Fuentes, Iris, Neelam, Sudha, Thompson, Bonne M, McDonald, Jeffrey G, DeBose-Boyd, Russell A
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402834/
https://ncbi.nlm.nih.gov/pubmed/30785396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44396
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