Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice

Autosomal-dominant Schnyder corneal dystrophy (SCD) is characterized by corneal opacification owing to overaccumulation of cholesterol. SCD is caused by mutations in UBIAD1, which utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K(2). Using cultured cells, we previously showed that...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Jo, Youngah, Hamilton, Jason S, Hwang, Seonghwan, Garland, Kristina, Smith, Gennipher A, Su, Shan, Fuentes, Iris, Neelam, Sudha, Thompson, Bonne M, McDonald, Jeffrey G, DeBose-Boyd, Russell A
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2019
Ämnen:
Biochemistry and Chemical Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402834/
https://ncbi.nlm.nih.gov/pubmed/30785396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44396
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