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Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi

UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K(2) subtype menaquinone-4. Previously, we found that sterols trigger binding of UBIAD1 to endoplasmic reticulum (ER)-localized HMG-CoA reductase, the rate-limiting enzy...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Schumacher, Marc M., Jun, Dong-Jae, Jo, Youngah, Seemann, Joachim, DeBose-Boyd, Russell A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918857/
https://ncbi.nlm.nih.gov/pubmed/27121042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M068759
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