Chimeric Agents Derived from the Functionalized Amino Acid, Lacosamide, and the α-Aminoamide, Safinamide: Evaluation of Their Inhibitory Actions on Voltage-Gated Sodium Channels, and Antiseizure and Antinociception Activities and Comparison with Lacosamide and Safinamide

[Image: see text] The functionalized amino acid, lacosamide ((R)-2), and the α-aminoamide, safinamide ((S)-3), are neurological agents that have been extensively investigated and have displayed potent anticonvulsant activities in seizure models. Both compounds have been reported to modulate voltage-...

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Veröffentlicht in:ACS Chem Neurosci
Hauptverfasser: Park, Ki Duk, Yang, Xiao-Fang, Dustrude, Erik T., Wang, Yuying, Ripsch, Matthew S., White, Fletcher A., Khanna, Rajesh, Kohn, Harold
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372064/
https://ncbi.nlm.nih.gov/pubmed/25418676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn5002182
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