Discovery of Lacosamide Affinity Bait Agents That Exhibit Potent Voltage-Gated Sodium Channel Blocking Properties

[Image: see text] Lacosamide ((R)-1) is a recently marketed, first-in-class, antiepileptic drug. Patch-clamp electrophysiology studies are consistent with the notion that (R)-1 modulates voltage-gated Na(+) channel function by increasing and stabilizing the slow inactivation state without affecting...

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Huvudupphovsmän: Park, Ki Duk, Yang, Xiao-Fang, Lee, Hyosung, Dustrude, Erik T., Wang, Yuying, Khanna, Rajesh, Kohn, Harold
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2012
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605825/
https://ncbi.nlm.nih.gov/pubmed/23509982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300188h
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