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Discovery of Lacosamide Affinity Bait Agents That Exhibit Potent Voltage-Gated Sodium Channel Blocking Properties
[Image: see text] Lacosamide ((R)-1) is a recently marketed, first-in-class, antiepileptic drug. Patch-clamp electrophysiology studies are consistent with the notion that (R)-1 modulates voltage-gated Na(+) channel function by increasing and stabilizing the slow inactivation state without affecting...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Chemical
Society
2012
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3605825/ https://ncbi.nlm.nih.gov/pubmed/23509982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300188h |
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