Identification of a Lacosamide Binding Protein Using an Affinity Bait and Chemical Reporter Strategy: 14-3-3 ζ

We have advanced a useful strategy to elucidate binding partners of ligands (drugs) with modest binding affinity. Key to this strategy is attaching to the ligand an affinity bait (AB) and a chemical reporter (CR) group, where the AB irreversibly attaches the ligand to the receptor upon binding and t...

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Bibliografiske detaljer
Main Authors:	Park, Ki Duk, Kim, Dong Wook, Reamtong, Onrapak, Eyers, Claire, Gaskell, Simon J., Liu, Rihe, Kohn, Harold
Format:	Artigo
Sprog:	Inglês
Udgivet:	2011
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3148493/ https://ncbi.nlm.nih.gov/pubmed/21692503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2034156
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Identification of a Lacosamide Binding Protein Using an Affinity Bait and Chemical Reporter Strategy: 14-3-3 ζ

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