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Development and Characterization of Novel Derivatives of the Antiepileptic Drug Lacosamide That Exhibit Far Greater Enhancement in Slow Inactivation of Voltage-Gated Sodium Channels
[Image: see text] The novel antiepileptic drug (R)-N-benzyl 2-acetamido-3-methoxypropionamide ((R)-lacosamide, Vimpat ((R)-1)) was recently approved in the United States and Europe for adjuvant treatment of partial-onset seizures in adults. (R)-1 preferentially enhances slow inactivation of voltage-...
Gorde:
| Egile Nagusiak: | , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Chemical Society
2010
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| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3082957/ https://ncbi.nlm.nih.gov/pubmed/21532923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn100089b |
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