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Development and Characterization of Novel Derivatives of the Antiepileptic Drug Lacosamide That Exhibit Far Greater Enhancement in Slow Inactivation of Voltage-Gated Sodium Channels

[Image: see text] The novel antiepileptic drug (R)-N-benzyl 2-acetamido-3-methoxypropionamide ((R)-lacosamide, Vimpat ((R)-1)) was recently approved in the United States and Europe for adjuvant treatment of partial-onset seizures in adults. (R)-1 preferentially enhances slow inactivation of voltage-...

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Main Authors: Wang, Yuying, Park, Ki Duk, Salomé, Christophe, Wilson, Sarah M., Stables, James P., Liu, Rihe, Khanna, Rajesh, Kohn, Harold
格式: Artigo
語言:Inglês
出版: American Chemical Society 2010
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082957/
https://ncbi.nlm.nih.gov/pubmed/21532923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn100089b
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