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Chimeric Derivatives of Functionalized Amino Acids and α-Aminoamides: Compounds with Anticonvulsant Activity in Seizure Models and Inhibitory Actions on Central, Peripheral, and Cardiac Isoforms of Voltage-gated Sodium Channels

Six novel 3″-substituted (R)-N-(phenoxybenzyl) 2-N-acetamido-3-methoxypropionamides were prepared and then assessed using whole-cell, patch-clamp electrophysiology for their anticonvulsant activities in animal seizure models and for their sodium channel activities. We found compounds with various su...

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Bibliographische Detailangaben
Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Torregrosa, Robert, Yang, Xiao-Fang, Dustrude, Erik T., Cummins, Theodore R., Khanna, Rajesh, Kohn, Harold
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461516/
https://ncbi.nlm.nih.gov/pubmed/25922183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.04.014
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