Substituted N-(Biphenyl-4′-yl)methyl (R)-2-Acetamido-3-methoxypropionamides: Potent Anticonvulsants That Affect Frequency (Use) Dependence and Slow Inactivation of Sodium Channels

[Image: see text] We prepared 13 derivatives of N-(biphenyl-4′-yl)methyl (R)-2-acetamido-3-methoxypropionamide that differed in type and placement of a R-substituent in the terminal aryl unit. We demonstrated that the R-substituent impacted the compound’s whole animal and cellular pharmacological ac...

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Main Authors: Lee, Hyosung, Park, Ki Duk, Torregrosa, Robert, Yang, Xiao-Fang, Dustrude, Erik T., Wang, Yuying, Wilson, Sarah M., Barbosa, Cindy, Xiao, Yucheng, Cummins, Theodore R., Khanna, Rajesh, Kohn, Harold
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2014
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111400/
https://ncbi.nlm.nih.gov/pubmed/25004277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500707r
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