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Synthesis and Anticonvulsant Activities of (R)-N-(4′-Substituted) benzyl 2-Acetamido-3-methoxypropionamides

The structure-activity relationship (SAR) for the N-benzyl group in the clinical antiepileptic agent (R)-lacosamide ((R)-N-benzyl 2-acetamido-3-methoxypropionamide, (R)-3) has been explored. Forty-three compounds were prepared and then evaluated at the National Institute of Neurological Disorders an...

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Detalhes bibliográficos
Main Authors: Salomé, Christophe, Salomé-Grosjean, Elise, Park, Ki Duk, Morieux, Pierre, Swendiman, Robert, DeMarco, Erica, Stables, James P., Kohn, Harold
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818974/
https://ncbi.nlm.nih.gov/pubmed/20041718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901563p
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