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Synthesis and anticonvulsant activities of N-benzyl (2R)-2-acetamido-3-oxysubstituted propionamide derivatives

Lacosamide has been submitted for regulatory approval in the United States and Europe for the treatment of epilepsy. Previous synthetic methods did not permit the elaboration of the structure–activity relationship (SAR) for the 3-oxy site in lacosamide. We report an expedient five-step stereospecifi...

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Autori principali: Morieux, Pierre, Stables, James P., Kohn, Harold
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701728/
https://ncbi.nlm.nih.gov/pubmed/18789868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.08.055
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