Initial Testing of the Hypoxia-Activated Prodrug PR-104 by the Pediatric Preclinical Testing Program

BACKGROUND: PR-104 is rapidly hydrolyzed to PR-104A in vivo, which is activated by reduction to the corresponding 5-hydroxylamine (PR-104H) and amine (PR-104M) to produce DNA interstrand cross-links. PR-104 activation can occur via hypoxia-dependent reductases and also independently of hypoxia by al...

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Publicado no:Pediatr Blood Cancer
Principais autores: Houghton, Peter J., Lock, Richard, Carol, Hernan, Morton, Christopher L., Phelps, Doris, Gorlick, Richard, Kolb, E. Anders, Keir, Stephen T., Reynolds, C. Patrick, Kang, Min H., Maris, John M., Wozniak, Amy W., Gu, Yongchuan, Wilson, William R., Smith, Malcolm A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304205/
https://ncbi.nlm.nih.gov/pubmed/21744473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22921
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