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The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1

The mTOR complex 1 (mTORC1) protein kinase is a master growth regulator that responds to multiple environmental cues. Amino acids stimulate, in a Rag-, Ragulator-, and v-ATPase-dependent fashion, the translocation of mTORC1 to the lysosomal surface, where it interacts with its activator Rheb. Here,...

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Pubblicato in:Science
Autori principali: Wang, Shuyu, Tsun, Zhi-Yang, Wolfson, Rachel, Shen, Kuang, Wyant, Gregory A., Plovanich, Molly E., Yuan, Elizabeth D., Jones, Tony D., Chantranupong, Lynne, Comb, William, Wang, Tim, Bar-Peled, Liron, Zoncu, Roberto, Straub, Christoph, Kim, Choah, Park, Jiwon, Sabatini, Bernardo L., Sabatini, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295826/
https://ncbi.nlm.nih.gov/pubmed/25567906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1257132
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