Critical Roles of Clostridium difficile Toxin B Enzymatic Activities in Pathogenesis

TcdB is one of the key virulence factors of Clostridium difficile that is responsible for causing serious and potentially fatal colitis. The toxin contains at least two enzymatic domains: an effector glucosyltransferase domain for inactivating host Rho GTPases and a cysteine protease domain for the...

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Li, Shan, Shi, Lianfa, Yang, Zhiyong, Zhang, Yongrong, Perez-Cordon, Gregorio, Huang, Tuxiong, Ramsey, Jeremy, Oezguen, Numan, Savidge, Tor C., Feng, Hanping
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Molecular Pathogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294253/
https://ncbi.nlm.nih.gov/pubmed/25404023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02316-14
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