A Segment of 97 Amino Acids within the Translocation Domain of Clostridium difficile Toxin B Is Essential for Toxicity

Clostridium difficile toxin B (TcdB) intoxicates target cells by glucosylating Rho GTPases. TcdB (269 kDa) consists of at least 4 functional domains including a glucosyltransferase domain (GTD), a cysteine protease domain (CPD), a translocation domain (TD), and a receptor binding domain (RBD). The f...

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Bibliografiske detaljer
Main Authors: Zhang, Yongrong, Shi, Lianfa, Li, Shan, Yang, Zhiyong, Standley, Clive, Yang, Zhong, ZhuGe, Ronghua, Savidge, Tor, Wang, Xiaoning, Feng, Hanping
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590123/
https://ncbi.nlm.nih.gov/pubmed/23484044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058634
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