Mutual exacerbation of PGC-1α deregulation and α-synuclein oligomerization

OBJECTIVES: Aggregation of α-synuclein (α-syn) and α-syn cytotoxicity are hallmarks of sporadic and familial Parkinson’s disease (PD) with accumulating evidence that prefibrillar oligomers and protofibrils are the pathogenic species in PD and related synucleinopathies. Peroxisome proliferator-activa...

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Pubblicato in:Ann Neurol
Autori principali: Eschbach, Judith, von Einem, Björn, Müller, Kathrin, Bayer, Hanna, Scheffold, Annika, Morrison, Bradley E., Rudolph, K. Lenhard, Thal, Dietmar R., Witting, Anke, Weydt, Patrick, Otto, Markus, Fauler, Michael, Liss, Birgit, McLean, Pamela J., La Spada, Albert R., Ludolph, Albert C., Weishaupt, Jochen H., Danzer, Karin M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293280/
https://ncbi.nlm.nih.gov/pubmed/25363075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24294
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