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Mutual exacerbation of PGC-1α deregulation and α-synuclein oligomerization
OBJECTIVES: Aggregation of α-synuclein (α-syn) and α-syn cytotoxicity are hallmarks of sporadic and familial Parkinson’s disease (PD) with accumulating evidence that prefibrillar oligomers and protofibrils are the pathogenic species in PD and related synucleinopathies. Peroxisome proliferator-activa...
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Publicado no: | Ann Neurol |
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Main Authors: | , , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4293280/ https://ncbi.nlm.nih.gov/pubmed/25363075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24294 |
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