Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington’s disease

PGC-1α is a versatile inducer of mitochondrial biogenesis and responsive to the changing energy demands of the cell. As mitochondrial ATP production requires proteins that derive from translation products of cytosolic ribosomes, we asked whether PGC-1α directly takes part in ribosomal biogenesis. He...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Jesse, Sarah, Bayer, Hanna, Alupei, Marius C., Zügel, Martina, Mulaw, Medhanie, Tuorto, Francesca, Malmsheimer, Silke, Singh, Karmveer, Steinacker, Jürgen, Schumann, Uwe, Ludolph, Albert C., Scharffetter-Kochanek, Karin, Witting, Anke, Weydt, Patrick, Iben, Sebastian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561056/
https://ncbi.nlm.nih.gov/pubmed/28819135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09148-7
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