Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington’s disease

PGC-1α is a versatile inducer of mitochondrial biogenesis and responsive to the changing energy demands of the cell. As mitochondrial ATP production requires proteins that derive from translation products of cytosolic ribosomes, we asked whether PGC-1α directly takes part in ribosomal biogenesis. He...

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Publicado no:Sci Rep
Main Authors: Jesse, Sarah, Bayer, Hanna, Alupei, Marius C., Zügel, Martina, Mulaw, Medhanie, Tuorto, Francesca, Malmsheimer, Silke, Singh, Karmveer, Steinacker, Jürgen, Schumann, Uwe, Ludolph, Albert C., Scharffetter-Kochanek, Karin, Witting, Anke, Weydt, Patrick, Iben, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561056/
https://ncbi.nlm.nih.gov/pubmed/28819135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09148-7
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